The correct answer is B) Oxidize Compound 4 and Compound 5 with IDO/H2O2, and identify the products.” “Of the experiments, which can be utilized to demonstrate that Compound 6 isn’t formed from either Compound 4 or Compound 5 sequentially?Ī) Conduct the reaction of Compound 4 with Compound 5, and identify the products.ī) Oxidize Compound 4 and Compound 5 with IDO/H2O2, and identify the products.Ĭ) Reduce pure Compound 6 without added catalyst, and identify the products.ĭ) Conduct the reaction of Compound 2 with H2O2 without added catalyst, and identify the products. When you combine this data trend with a solid understanding of enzyme kinetics, you may conclude that L-Trp is clearly inhibiting said reaction. The kcat in the example represents the product turnover rate, which indicates that the enzyme produces a reduced amount of product in the presence of L-Trp. The examinee needs to comprehend the meaning behind decreasing kcat values in the presence of higher concentrations of L-Trp in terms of the kinetics of IDO-catalyzed indole oxidation. Rationale: Here, the examinee must use their knowledge of enzyme kinetics combined with their ability to interpret data. The correct answer is D) L-Trp inhibits the enzyme.” “These kinetic parameters have been obtained for IDO-catalyzed oxidation of Compound 3 by H2O2 in the presence of L-Trp.Ĭonsidering the above data, what is the effect of L-Trp on the reaction?ī) L-Trp is oxidized instead of Compound 3.Ĭ) L-Trp does not interact with the enzyme. The examinee should draw the conclusion that, based on the presence of additional groups in the products of the reaction, the most effective method to monitor information on the product formation is by the appearance of a peak between 1700–1750 cm–1 in the IR spectrum. The examinee must then apply this model to the experiment shown in the above passage. The examinee has to work with the scientific model, which shows the differences in IR absorbance of multiple functional groups. Rationale: In this question, the examinee must call upon their knowledge of infrared spectroscopy and explain why structural differences appear in Reaction 2 between the reactants and the products. The correct answer is C) Appearance of a sharp peak at 1700–1750 cm–1.” “What change to the IR spectrum of the product mixture can be observed to monitor the progress of Reaction 2?Ī) Appearance of a broad peak at 3400 cm–1ī) Disappearance of a broad peak at 3400 cm–1Ĭ) Appearance of a sharp peak at 1700–1750 cm–1ĭ) Disappearance of a sharp peak at 1700–1750 cm–1 Which experiment can be used to show that Compound 6 is not formed sequentially from either Compound 4 or Compound 5?Ī) Conduct the reaction of Compound 4 with Compound 5, and identify the products.ī) Oxidize Compound 4 and Compound 5 with IDO/H 2O 2, and identify the products.Ĭ) Reduce pure Compound 6 without added catalyst, and identify the products.ĭ) Conduct the reaction of Compound 2 with H 2O 2 without added catalyst, and identify the products.Question 1. Combining this trend in the data with a knowledge of enzyme kinetics, it can be concluded that L-Trp is inhibiting the reaction.ģ. The k cat is representative of the rate of product turnover, which means that the enzyme produces less product in the presence of L-Trp. The test taker must understand what the decreasing values of k cat in the presence of higher concentrations of L-Trp mean with respect to the kinetics of IDO-catalyzed indole oxidation. Rationale: This question requires the test taker to combine knowledge of enzyme kinetics with interpretation of data. Training Opportunities for Residents and FellowsĬorrect Answer is D) L-Trp inhibits the enzyme.ERAS® Tools and Worksheets for Fellowship Applicants.ERAS® Tools and Worksheets for Residency Applicants.MyERAS® Application and Program Signaling for 2023-24.ERAS® 2024 Participating Specialties & Programs.Managing Your Finances During Residency.Interview Resources for Residency Applicants.Researching Residency Programs and Building an Application Strategy.Visiting Student Learning Opportunities™ (VSLO®).
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